Functional Ingredients

Celiac/gluten intolerance: Is lack of vitamin C to blame?

Avoidance is one strategy to overcome gluten intolerance but defensive maneuvers may be more practical.

The current craze in natural medicine is gluten free. Medically the problem is called celiac disease and it involves the deterioration of the mucus barrier in the small bowel as a result of the innate immune system over-responding to an allergen.

However, celiac disease genetically involves only 1 to 2 percent of human populations. You couldn't sell all those gluten-free foods to such a small group. It's as if every unexplained health problem now is being blamed on gluten and grains. People are avoiding whole grains like D Dracula avoided a ring of garlic.

Avoidance is one strategy to overcome gluten intolerance but defensive maneuvers may be more practical. Some doctors in Europe are on a different track to conquer this seemingly widespread but certainly growing problem. They explain that life-long avoidance of gluten is burdensome and probably not achievable given trace amounts in other foods via contamination.

These researchers point to an overlooked study published last year where researchers obtained biopsies from patients with celiac disease and added some ascorbate (vitamin C) to lab dishes containing gut tissue. The effects were dramatic. The various inflammatory markers (INF-a & y, TNF, IL-13, 16, 17) were abolished in the vitamin C-treated dishes!

What can we conclude from the evidence showing a shortage of vitamin C may reduce natural defenses against gluten? Dare we say the obvious? That the evidence presentedhere points to another conclusion: Mankind is suffering from yet another manifestation of scurvy.

For those with sensitive digestive tracts, the buffered mineral ascorbate forms of vitamin C may be better tolerated or even the fat-soluble ascorbyl palmitate form of vitamin C.

Discuss this article 4

The study mentioned has something left to be desired with conclusiveness about celiac disease and gluten intolerance being cured with vitamin C. The inflammatory markers that were abolished with addition of vitamin C in the lab really proves nothing other than vitamin C is anti inflammatory and does turn off these markers in the body. Both celiac disease and gluten intolerance have been found to have a genetic component that turns on an immune response in the gut. I believe that low level stress over long periods of time does reduce vitamin C levels along with zinc. This leaves one with a sluggish immune system and perhaps leaves one more vunerable to having genes turned on for gluten intolerance but no amount of vitamin C dosing will turn genes off or cure gluten intolerance or celiac disease.

By jmcginnis  on Dec 11, 2011

Thanks for your comment--interesting points about the complex relationship between genes, immunity, and nutrients.

By susanesrey  on Dec 13, 2011

This article is cheap journalism and should never have been permitted on a site such as this where ordinary people actually come for advice and guidance.

Where to start? The writer refers to an 'overlooked' study published last year...is there any wonder it was overlooked? This is so misleading as to be total crock.

Any way you approach gluten, literally from any angle, it is harmful to the human body; to suggest we can simply pop a vitamin pill and have done with it is farcical.

And has the writer been following the antioxidant story? All the meta-analyses are now showing that if you take Vitamin C (among others), it increases overall mortality. It appears that the body is best off if it gets its chance to fight things on its own first, whether it’s oxidation, a bacteria or a microbe. If the body sends forward its own defences first and understands how to do that, it’s better equipped to deal with the challenge, and whether it’s Vitamin C or an antibiotic, if it’s added too early, then the body’s own response never gets smart enough to deal with the challenge on its own.

And while I am here, can I just point out that 1 to 2 percent of human populations ("...You couldn't sell all those gluten-free foods to such a small group.") is actually a vast number of people...

Please, sharpen up your act and give us accurate and worthy commentary.

By jason  on Dec 14, 2011

I don’t think that vitamin C could be a long term cure for celiac disease as it is a genetic problem. But there are certain enzymes that may provide near-term relief for celiac. I’ve worked with several vitamin manufacturers over the years for contract manufacturing supplements. Many of them have suggested food grade proteases from Aspergillus niger and Aspergillus oryzae for gluten detoxification. I own a health food shop, sell my own brand and these enzymes have shown some positive results for customers who prefer a gluten free diet and for those who are gluten-intolerant.

By IanBradley  on Mar 14, 2012
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