Caralluma fimbriata extract may aid in slimming the waist, according to new research.

As recently published in the journal Complementary Therapies in Medicine, Australian researchers assessed the effects of Caralluma fimbriata on 33 overweight and obese Australian men and women. Study participants took either a placebo or 500 mg of Caralluma fimbriata extract twice daily, while having their exercise and dietary intake controlled and monitored. At the end of 12 weeks, those who received the Caralluma fimbriata supplement had lost an average of 2.6 inches from their waists, compared to only 1 inch from the placebo group.

Caralluma fimbriata is an edible succulent plant, native to India. Indian tribal people have used the natural appetite suppressant for many centuries. In times of famine it is a commonly used vegetable.

“This and other studies show that supplementation with Caralluma fimbriata can lead to a clinically meaningful reduction in central adiposity,” said Dr. Paul Clayton, chief scientific advisor for Gencor, which provided the raw Caralluma fimbriata extract powder for the study. “In conjunction with exercise and a controlled diet, Caralluma fimbriata can improve metabolic risk factors, general health and well-being. The latest research at Carolina State University, which reveals how pregnane glycosides (the actives in Caralluma) inhibit appetite, validates the clinical results and puts Caralluma at the head of the class of natural weight loss products.”

Caralluma fimbriata is available through the ingredient Slimaluma®, developed by Gencor, which specializes in providing unique herbal solutions for lifestyle management. By utilizing a patented process that extracts the active compounds of the whole herb without disrupting the biochemical framework, Gencor ensures the full benefits of the herb are delivered in concentrated form.

Slimaluma is currently available as a key ingredient in several brands, including Slimaluma Plus, GenaSlim, and Slenderluma.

Gencor has conducted two human clinical trials and six safety studies to ensure the safety and efficacy of Slimaluma. In 2006, Slimaluma was affirmed GRAS (Generally Recognized as Safe). It is certified Kosher, Halal and Organic, and meets DSHEA requirements under section 413(a)(1).

The appetite suppressing properties of Caralluma fimbriata have been attributed to the active component pregnane glycosides. The mechanism of appetite suppression of pregnane glycosides is unclear, however one hypothesis is that Caralluma fimbriata may down-regulate ghrelin synthesis in the stomach and neuropeptide-Y in the hypothalamus, resulting in appetite suppression.