| Supplement | Details | Dosage | Warnings |
| Coenzyme Q10 | A study by Philadelphia’s Jefferson Headache Center found that a daily dose of Co-Q10 cut the frequency of headaches by 50 percent among two-thirds of migraine sufferers. | 150 mg/day | Do not use if you are taking warfarin, an anticoagulant. |
| Feverfew (Tanacetum parthenium) | This herb’s pain-relieving and inflammation-fighting properties have been clinically shown to reduce the frequency and severity of migraines. | Up to 250 mg/day of a standardized supplement containing at least 0.4% parthenolides | Do not use if you are taking blood-thinning drugs or during pregnancy or lactation. |
| Fish oil | Clinical studies have found that supplemental fish oil is a natural anti-inflammatory that can reduce the frequency, severity, and duration of migraines. | 3,000 mg/day | No known side effects. Safe for use during pregnancy or lactation. |
| Magnesium | People with frequent headaches tend to have low levels of this important mineral. Combining magnesium with feverfew may be more effective than taking either supplement alone. | 250–350 mg/day | Taking more than 350 mg/day may cause diarrhea. |
| 5-HTP | Research shows that this natural amino acid is effective for taming both tension headaches and migraines. | 100 mg, 3x/day for tension headaches | May cause stomach upset. Do not use if you are taking anti-depressants or during pregnancy or lactation. |