Cognizin® (Citicoline)

Product Benefit Statement

Clinical research has found that Cognizin supports the health of mitochondria, the powerhouses within cells that actually produce the brain’s energy.* Healthy mitochondrial function results in higher levels of ATP—the body’s main energy storage molecule—in brain cells.


The second brain-health benefit of Cognizin Citicoline is increased focus and concentration.
Cognizin’s third brain-health benefit is improved memory storage and recall.* Cognizin Citicoline is often called a “brain nutrient” because it increases levels of several important neurotransmitters, including acetylcholine, an important brain chemical that regulates memory and cognitive function. Cognizin has also been shown to support the activity of nerves that respond to acetylcholine, helping to raise activity levels in the brain’s learning and memory circuits.

Product Description

Discover the difference Cognizin® can make in your functional food and beverage products. Cognizin is a proprietary form ofciticoline, a potent brain-health nutrient clinically shown to support mental energy, focus, attention and recall.* Tested in human clinical trials and developed using a patented fermentation process, Cognizin is a pure, vegetarian, allergen-free,

GRAS ingredient that’s stable and effective.* For a functional difference consumers are sure to notice, add the proven brain power of Cognizin to your next product.


_ Provides the compound needed for the synthesis of phosphatidylcholine, a major constituent of brain tissue* 1, 2, 3, 4, 5
_ Enhances communication between neurons to support visual function* 6, 7
_ Helps protect neural structures from accumulating free-radical damage* 4
_ Supports brain performance by enhancing metabolism and healthy brain activity* 6,8,9
_ Assists in sustaining healthy mitochondria in the brain, the energy factories inside brain cells* 6, 8, 9
_ Supports healthy brain metabolism by nourishing and maintaining brain cell phospholipids* 3, 4, 5
_ Helps maintain normal levels of acetylcholine, a chemical that helps regulate memory and cognitive function* 6, 10

1. Wurtman RJ et al. Biochem Pharmacol. 2000; 60(7):989-92.
2. Rao AM et al. J Neurosci Res. 1999; 58(5):697-705.
3. Lopez-Coviella I et al. J Neurochem. 1995; 65(2):889-94.
4. Conant R, Schauss AG. Alt Med Rev. 2004; 9:1, 17-31.
5. Babb SM et al. Psychopharmacology (Berl). 2002; 161:248-54.
6. Fiorvanti M, Yanagi M. The Cochrane Library, Oxford, England. 2006: Issue 4.
7. Secades JJ, Lorenzo JL. Meth Find Exp Clin Pharmacol. 2006; 27 (Suppl B):1-56.
8. Watanabe S et al. Folia Psychiatr Neurol Jpn. 1975; 29(1):67-76.
9. Silveri MM et al. NMR Biomed. 2008; 21(10):1066-75.
10. Spiers PA et al. Arch Neurol. 1996; 53:441-48.

Industry Scorecard
Standards Approval Trade Association Research Peer Review
Product Datapoints
Intellectual Property
Registered Trademark,
Patent Pending
Clinical Research
Research Type
Placebo -controlled Clinical Study (Gold Standard)
Research Publish Status
Peer-reviewed Journal
Purity Level %
Not less than 98%
Quality Comment
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