Sustamine™ L-Alanyl-L-Glutamine

Product Benefit Statement

Sustamine™ health benefits include more rapid absorption of water and electrolytes in your intestines, the promotion of the synthesis of glycogen and muscle protein, as well as protection of protein once it’s formed. Sustamine can improve the uptake of nutrients in your GI tract.
In research trials, it was shown that the Sustamine L-Alanyl-L-Glutamine was more effective at improving water and electrolyte uptake than L-Glutamine by itself. L-Alanine’s main role in the body is to renew glycogen stores.
Rehydration with Sustamine also appears to maintain skill performance and visual reaction time to a greater extent than water only.

Product Description

Sustamine™ L-Alanyl-L-Glutamine, is a stable dipeptide derivative of L-Alanine and L-Glutamine. Awarded the best Ingredient for Beverages: Kyowa Hakko, Sustamine. The amino acids L-alanine and L-glutamine are easily absorbed to benefit muscles. The dipeptide Sustamine is water-soluble, GRAS, and also taste- and odor-free, making it perfect for rehydration and recovery drinks.

_ Sustamine enhances electrolyte and water absorption in the intestines. * 2, 4
_ Sustamine stimulates glycogen synthesis.* 5
_ Sustamine inhibits muscle protein breakdown.* 6, 7
_ Sustamine promotes the synthesis of muscle protein.* 1, 7
_ Sustamine helps protect the integrity of the gastrointestinal trace, contributing to better nutrient absorption.* 6, 8
_ Sustamine helps support the immune system.* 9, 10
_ Sustamine research suggests that supplementation conveys a significant ergogenic benefit by increasing time to exhaustion under conditions of mild dehydration.

1. Rogero, M.M., et al., Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise. Nutrition, 2006. 22(5): p. 564-71.
2. Cruzat, V.F., M.M. Rogero, and J. Tirapegui, Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochem
Funct, 2010. 28(1): p. 24-30.
3. Hoffman, J.R., et al., Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. J Int Soc Sports Nutr. 7: p. 8.
4. Lima, A.A., et al., Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. Nutrition, 2002. 18(6): p. 458-62.
5. Rennie, M.J., et al., Interaction between glutamine availability and metabolism of glycogen, tricarboxylic acid cycle intermediates and glutathione. J Nutr, 2001. 131(9 Suppl): p. 2488S-90S; discussion 2496S-7S.
6. Miller, A.L., Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev, 1999. 4(4): p. 239-48.
7. Welbourne, T.C., Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr, 1995. 61(5): p. 1058-61.
8. Braga-Neto, M.B., et al., Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro. Dig Dis Sci, 2008. 53(10): p. 2687-96.
9. Roth, E., Nonnutritive effects of glutamine. J Nutr, 2008. 138(10): p. 2025S-2031S.
10. Castell, L., et al., Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J Biol Chem, 2004. 279(14): p. 13305-10.

Industry Scorecard
Standards Approval Trade Association Research Peer Review
Product Datapoints
Intellectual Property
Registered Trademark,
Patent Pending
Clinical Research
Research Type
Placebo -controlled Clinical Study (Gold Standard)
Research Publish Status
Peer-reviewed Journal
Odorless, white crystalline powder
Purity Level %
98- 102%